Careers

Our company was founded on the premise that protein motion can be leveraged to create breakthrough medicines. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients’ lives.

We’re tackling a wide array of compelling target opportunities with an approach that gives us the ability to discover best-in-class drugs in cancer and multiple other areas of high unmet medical need. We’d be nothing without a visionary team that not only pulls it all together, but is willing to stand behind an exciting novel approach.

Our world-class team is equal parts bright and bold, with a shared passion for working in intellectually stimulating environments. We look for people who are committed to working together in a collaborative, rigorous and entrepreneurial culture. We’ve created the kind of work environment that not only gets, but keeps people excited and focused–and we’ve mastered the art of sharing our findings in ways that both educate and inspire. Putting protein motion at the heart of drug discovery will be a challenge, but we are confident that our team’s dedication and urgency will create opportunities that profoundly impact the lives of the patients we serve. 

Headquartered in Cambridge, Mass., Relay Therapeutics is a private company launched with $57M Series A financing from Third Rock Ventures and from an affiliate of D. E. Shaw Research.

Relay invites extraordinarily creative, talented and passionate individuals to join us as we strive to make a difference in patients’ lives. We offer competitive compensation along with a comprehensive benefits package and we recognize the achievements of our employees. Our culture fosters collaboration and excellence. Join our team!

CURRENT OPENINGS

  • Associate Director / Director, Pharmacology

    The Company:

    Relay Therapeutics was founded on the premise that protein motion can be leveraged to create breakthrough medicines. The team at Relay is putting this principle into practice, with the aim of accelerating the development of medicines that will make a transformative difference in patients’ lives.  We’re tackling a wide array of compelling target opportunities with an approach that gives us the ability to discover best-in-class drugs in cancer and multiple other areas of high unmet medical need. We’d be nothing without a visionary team that not only pulls it all together, but is willing to stand behind an exciting novel approach.

    The Position:

    Relay Therapeutics is seeking a pharmacology leader to enable the development of small molecule therapies for cancer and related diseases.  The individual in this essential role will lead the design, external execution, and interpretation of in vivo pharmacology studies to support a growing pipeline of anti-cancer agents.  The ideal candidate has broad and diverse experience with oncology and immuno-oncology models, has led in vivo studies to assess PK/PD/efficacy relationships, and has experience overseeing interactions with contract research organizations.   Candidates must enjoy an interactive environment in which they will be asked to influence the strategy of multiple project teams.

    Responsibilities:

    • Lead the pharmacology strategy as part of cross-functional drug discovery teams
    • Lead the design, external execution, and interpretation of in vivo PK/PD/efficacy studies, ensuring high quality, timely completion, and appropriate cost
    • Work closely with DMPK experts on PK/PD modeling, and study execution
    • Work with external academic and industrial collaborators to lead in vivo studies performed in complex disease models
    • Present clearly and concisely in internal and external meetings

    Qualifications:

    • PhD in oncology, pharmacology, or related field with at least 5 years of industry experience in small molecule drug discovery
    • Broad experience with diverse animal models of cancer and anti-tumor immunity, including patient-derived and genetically-engineered models
    • Demonstrated track record of leading pharmacology studies to support research stage drug discovery programs
    • Strong organizational and time management skills, with track record of supporting multiple ongoing projects in parallel
    • Experience with biomarker assay development and validation is a plus
  • Director, DMPK

    The Position

    Relay is seeking a highly motivated and well accomplished scientist to join our team.  In this  hands-on role, the Director, DMPK who will be responsible for:

    • Providing DMPK expertise on multi-disciplinary drug discovery and development teams
    • Guiding discovery project teams for candidate selection, developing and driving DMPK strategies for lead optimization and solving ADME issue, designing in vitro and in vivo DMPK studies and interpreting results
    • The application of modeling approaches (in silico, PK, PBPK) to support human pharmacokinetics and dose predictions and quantitative risk assessment of drug-drug interactions, conducting PK/PD modeling, monitoring of GLP bioanalysis, and CRO management
    • As compounds progress into clinical development, this person may be responsible for the clinical pharmacokinetic aspect of clinical trials.
    • The candidate will be required to generate, analyze and present data, both orally and as written reports
    • Authoring and/or reviewing various regulatory documents

    Qualifications·

    • Proven track record of supporting drug discovery and development as DMPK project
    • PhD in Pharmacokinetics, Pharmaceutical Sciences, or related field with a specific focus on pharmacokinetics with a minimum of 8 years of relevant industry experience is required
    • representative on multifunctional project teams is required
    • Extensive understanding of DMPK principles is required
    • Extensive experience in setting up LC-MS based bioanalytic methods
    • Proven skills in pharmacokinetic modeling, including application of SimCyp and/or Gastroplus PBPK, Phoenix WinNonlin, and/or NONMEM are preferred
    • Monitoring of DMPK studies at CRO is preferred
    • Knowledge of GLP, development and regulatory guidelines is desirable
    • Previous experience in regulatory filing is desirable
    • The ability to work independently, excellent interpersonal, organizational, oral/written communication and teamwork skills, ability to multi task and prioritize to delivery results within tight timelines are required
  • Research Associate / Senior Research Associate, Biology

    Position Summary

    Relay Therapeutics is seeking a self-motivated researcher a desire to excel at the highest level to join a team of scientists driving the discovery of novel small molecule therapeutics in oncology.   The successful candidate will design and execute molecular and cell biology experiments focused on the discovery/validation of new drug targets, evaluation of candidate molecules, and development of novel biomarkers. A considerable level of independence is expected after the initial training period. S/he will interact and collaborate cross-functionally with scientists in other departments, including biochemists, chemists, and computational biologists.  Significant project ownership will allow for acquisition of new skills and for learning additional facets of the drug discovery process as projects advance.

    Job Responsibilities

    • Design and perform cell and molecular biology experiments to support the biological evaluation of small molecules impacting cancer dependencies and anti-cancer immunity
    • Develop cell-based assays to be used in target validation studies and/or medium throughput screening campaigns
    • Conduct cell-based assays in support of medicinal chemistry efforts and structure activity relationship assessment
    • Develop and perform pharmacodynamic and patient selection biomarker assays
    • Maintain good written records of laboratory procedures, results and conclusions.
    • Perform and report interim analysis of accumulated data to monitor work progress.

    Qualifications

    • BS/MS with 3+ years of industry/academic experience working in a cancer biology team
    • Experience in molecular biology (nucleic acid purification, DNA cloning, PCR, gel electrophoresis, Western blotting, and qPCR, si/shRNA, CRISPR, lentiviral gene knockdown)
    • Exceptional cell biology capabilities (mammalian cell culture flow cytometry, microscopy). Experience with in vitro immunology assays is a plus
    • Ability to design and execute experiments, analyze and document results
    • Excellent organizational and communication skills
    • Excellent problem-solving skills and ability to multi-task

Career Inquiries:

CAREERS@RELAYTX.COM

Relay Therapeutics is an equal opportunity employer and will not discriminate against any employee or applicant on the basis of age, color, disability, gender, national origin, race, religion, sexual orientation, veteran status, or any classification protected by federal, state, or local law.

Core Values

Fearless

Pursuing groundbreaking medicines by focusing on protein motion.

Relentless

Sustained urgency because patients can’t wait.

Candor

Openness through respect, listening, and speaking up.

Craftsmanship

Our best work, with passion, pride, and excellence.

Humanity

Accomplishing great things through generosity, enthusiasm, and collaboration.